ea0009p149 | Thyroid | BES2005
O'Shea P
, Sriskantharajah S
, Yao H
, Suzuki H
, Cheng S
, Chassande O
, Samarut J
, Williams G
T3, GH and IGF-1 are essential for skeletal development. GH acts directly on growth plate chondrocytes and also via a local paracrine pathway involving IGF-1, but it is unclear whether T3 stimulates bone formation directly or indirectly. To address this, we determined expression of GH-receptor, IGF-1 and IGF-1 receptor (IGF-1R) by in situ hybridisation and activation of downstream STAT5 and AKT signalling by immunohistochemistry in growth plates from four T3-receptor (TR) muta...